Wellbutrin (bupropion) is a medication prescribed for depression and smoking cessation. Unlike most antidepressants, which often lead to weight gain, Wellbutrin is known for its potential to promote weight loss in many patients.
Healthcare providers may recommend Wellbutrin to patients concerned about weight gain from other antidepressants. If you're interested in learning more about how Wellbutrin can aid in weight loss and whether it's suitable for you, read on.
What is Wellbutrin?
Wellbutrin (bupropion) is classified as an NDRI (norepinephrine-dopamine reuptake inhibitor). It works by increasing the levels of norepinephrine and dopamine in the brain.
Bupropion is available in generic form and under various brand names, including:
- Aplenzin
- Budeprion SR
- Budeprion XL
- Buproban
- Forfivo XL
- Wellbutrin
- Wellbutrin SR
- Wellbutrin XL
- Zyban (discontinued)
Bupropion is FDA-approved for treating major depressive disorder (MDD) and seasonal affective disorder (SAD). It is also approved under the brand name Contrave, which combines bupropion and naltrexone for weight management. Previously, it was marketed as Zyban for smoking cessation, though this has been discontinued.
Does Wellbutrin Cause Weight Loss?
Yes, bupropion (the generic form of Wellbutrin) can lead to weight loss. A 2016 study found that non-smokers taking bupropion lost an average of 7.1 pounds over two years, whereas other antidepressants in the study were associated with weight gain.
Bupropion has also been shown to help maintain weight loss. A 2012 study revealed that adults with obesity who took bupropion SR (300mg or 400mg) lost 7.2% to 10% of their body weight over 24 weeks and maintained this loss at 48 weeks. Additionally, a 2019 review of 27 studies on antidepressants and weight gain indicated that most antidepressants increase body weight by about 5%, except for bupropion, which is linked to weight loss.
Uses of Wellbutrin
Wellbutrin (bupropion) is FDA-approved for several purposes but can also be used to treat a variety of other conditions. A licensed healthcare provider can prescribe Wellbutrin for both its approved uses and for off-label purposes.
Approved Uses:
- Adult Depression
- Seasonal Affective Disorder (SAD)
- Smoking Cessation
Off-label Uses:
- Anxiety
- Sexual Dysfunction
- Depression related to bipolar disorder or obesity
- Fatigue
- Social Anxiety Disorder
- Post-Traumatic Stress Disorder (PTSD)
- Attention-Deficit/Hyperactivity Disorder (ADHD)
- Neuropathic Pain
How Does Wellbutrin Aid in Weight Loss?
Although the FDA has not officially approved bupropion for weight loss, it is one of the active ingredients in Contrave, a weight loss drug that is FDA-approved.
A 2016 study highlighted significant long-term weight loss results with bupropion. The medication may aid weight loss efforts by:
- Boosting energy levels
- Suppressing appetite
- Enhancing mood
- Reducing stress
Will Everyone Lose Weight on Wellbutrin?
Wellbutrin has shown positive results in certain individuals, especially overweight and obese women, but it may not be effective for everyone dealing with weight management issues.
If you tend to eat more when stressed, Wellbutrin could be beneficial as it helps to decrease stress and improve mood. However, if poor eating habits are the main issue, Wellbutrin may not be as effective.
When Will I See Weight Loss Results?
Clinical trials have demonstrated that subjects taking 400 milligrams of Wellbutrin per day lost double the percentage of body weight compared to those taking a placebo. However, Wellbutrin is primarily used to treat depression, not as a weight loss drug, and it may not work for everyone. Results may typically start to appear around eight weeks.
How Much Weight Can I Lose on Wellbutrin?
The amount of weight loss varies based on several factors. Patients may experience more significant weight loss if they:
- Have a higher body mass index (BMI)
- Follow a healthy eating plan
- Create a caloric deficit (consume fewer calories or increase physical activity)
- Exercise regularly
- Use Contrave, which combines bupropion and naltrexone
How Much Wellbutrin Should I Take for Weight Loss?
Always consult a healthcare provider for appropriate dosages, but taking 300 to 400 mg of Wellbutrin per day has been shown to yield good weight loss results.
Achieving weight loss is challenging, regardless of the method. By discussing your goals and limitations with your doctor, they can recommend weight loss strategies and medications that are suitable for you.
Should I Use Wellbutrin for Weight Loss?
While many antidepressants can cause weight changes, bupropion (Wellbutrin) may not lead to weight loss for everyone. In some cases, Wellbutrin can even cause weight gain. It’s essential to discuss your weight loss goals with your doctor before starting treatment.
People who tend to overeat when stressed often see better weight loss results with Wellbutrin compared to those who do not have emotional eating habits. Your doctor can suggest other weight loss medications that might be more suitable for you.
How to Enhance Weight Loss with Wellbutrin
To maximize weight loss while taking Wellbutrin, consider these additional strategies:
Eat a Balanced Diet: Consult a dietitian or nutritionist to create a sustainable meal plan with a caloric deficit.
Avoid Empty Calories: Cut down on sugary drinks and processed foods, and limit alcohol intake.
Exercise Regularly: Incorporate physical activity into your daily routine.
Stay Hydrated: Drink plenty of water and reduce your intake of sugary beverages.
Improve Sleep: Ensure you get enough quality sleep to help regulate hunger signals.
Increase Fiber Intake: Eating more fiber can help you feel fuller for longer.
Monitor Progress: Instead of frequently weighing yourself, look for other signs of weight loss, such as clothing fitting more loosely.
Stay Consistent: Consistency is key to achieving and maintaining weight loss.
Side Effects of Wellbutrin
Wellbutrin can have side effects, which can be common or uncommon:
Common Side Effects:
- Sleep disturbances
- Rapid heartbeat
- Headache
- Dry mouth
- Nausea
Uncommon Side Effects:
- Restlessness
- Anxiety
- Constipation
- Dizziness
- Fatigue
- Seizures
- Suicidal thoughts
- Delusions and paranoia
- High blood pressure
- Severe allergic reactions
- Manic episodes
- Eye problems
To minimize severe side effects, follow these guidelines:
- Take Medication as Directed: Always use Wellbutrin as prescribed.
- Inform Your Doctor: Discuss all other medications you are taking.
- Communicate Concerns: Talk to your doctor about any side effects or dosage adjustments.
- Avoid Alcohol and Drugs: Refrain from using substances that can interact negatively with Wellbutrin.
- Maintain a Healthy Diet: Eating well can help manage side effects.
If you experience severe side effects or have concerns about your medication, contact your healthcare provider immediately.
Other Weight Loss Strategies
Apart from medication, consider these tips for weight loss:
- Eat Breakfast: Start your day with a healthy meal.
- Regular Meals: Eat at consistent intervals.
- Food Journaling: Keep track of your food intake.
- Exercise: Make physical activity a regular part of your routine.
- Stay Hydrated: Drink water throughout the day.
- High-Fiber Foods: Include more fiber-rich foods in your diet.
- Quality Sleep: Ensure you get enough restful sleep.
- Smaller Plates: Use smaller plates to help control portion sizes.
- Home-Cooked Meals: Prepare healthy meals at home instead of ordering takeout.
- Limit Sugars and Alcohol: Reduce intake of refined sugars and alcohol.
- Plan Ahead: Plan your meals in advance to avoid unhealthy choices.
- Consult Professionals: Seek advice from dietitians or nutritionists for a better understanding of food choices.
When to See a Doctor for Weight Loss
Before starting any new diet or exercise program, especially if you have medical conditions like high blood pressure or diabetes, consult your doctor. They can ensure your plan is safe and effective.
Schedule an appointment with your doctor if you:
- Experience unexplained weight gain.
- Struggle to lose weight despite diet and exercise efforts.
- Are obese and at higher risk for health issues.
- Are overweight with depressive symptoms.
- Have health problems directly related to your weight.
- Need to lose weight for a surgical procedure.
- Suspect an underlying condition that hinders weight loss.
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